Assertion : A change in nitrogen base at the third position of a codon causes change in the expressi

Question

Assertion : A change in nitrogen base at the third position of a codon causes change in the expression of the codon.\ Reason : The pairing of the third position bases of the codon may be ambiguous and varies according to the nucleotide present in this position.\

Professor PC Thomas Classes · Answer

(d) : According to the Wobble hypothesis, only the first two position of a triplet codon on mRNA have a precise pairing with the bases of the tRNA anticodon. The pairing of the third position bases of the codon may be ambiguous and varies according to the nucleotide present in this position. Thus, a single tRNA type is able to recognise two or more codons differing only in the third base. The same is called wobble position.